Ability of Isopregnenolone-21-Carboxylates to Block Renal Effects of Deoxycorticosterone and Aldosterone in Rats

Abstract

Studies demonstrate that isopregnenolone-21-carboxylates are potent inhibitors of the renal electrolyte effects of deoxycorticosterone in adrenalectomized rats. 3-Oxo-9[alpha] -fluoro-11[beta], 17[beta]-dihydroxy-17[alpha] -pregn-4-ene-21-carboxylic acid as the potassium salt, the most potent of 4 compounds in the series, was also effective against aldosterone. Available evidence indicates that the compounds affect electrolyte excretion by competition with aldosterone-like steroids at receptor sites in target tissue.