The efficacy of strophanthin in cardiac failure was studied carefully in a large series of patients by Fraenkel7 in 1906 and by Vaquez23 in 1909. Their enthusiastic reports stimulated great interest in the therapeutic possibilities of this drug with the result that numerous observers soon corroborated their favorable results. The scope of this report is too limited to permit a complete survey of the very extensive literature on this subject, but the excellent monograph of Fraenkel8 will be found to contain a critical digest of practically all work done on the pharmacological and clinical aspects of strophanthin. It can be