Serum Amyloid P and Cardiovascular Disease in Older Men and Women

Abstract

Objective— Serum amyloid P (SAP), a pentraxin like C-reactive protein (CRP), functions in innate immunity. However, associations of SAP with cardiovascular disease (CVD) are unknown. Methods and Results— We examined these associations in the Cardiovascular Health Study using a case–cohort design. Nonexclusive case groups were incident angina (n=523), myocardial infarction (MI; n=308), stroke (n=323), and CVD death (n=288). 786 participants had no events. SAP was correlated with CRP, CVD risk factors (obesity, blood pressure, lipids), common and internal carotid wall thickness, and ankle-brachial index (all PConclusions— Although both are pentraxins, SAP and CRP may represent different facets of inflammation. The association of SAP with CVD in these older adults further supports the role of innate immunity in atherosclerosis. Serum amyloid P (SAP) is a pentraxin similar to C-reactive protein. We examined the association of SAP with cardiovascular disease (CVD) in older adults. SAP was associated with inflammatory markers, CVD risk factors, measures of subclinical CVD, and incident angina and MI.