Isolation of a trimer of α‐tocopherol from mammalian liver
- 1 January 1967
- Vol. 2 (1), 47-54
- https://doi.org/10.1007/bf02532000
Abstract
Evidence is presented for the formation in mammalian liver of a trimeric metabolite of α-tocopherol. This compound has been shown to be identical to a trimer produced by oxidation of α-tocopherol with alkaline K3Fe(CN)6. In addition, confirmation was obtained for the occurrence in vivo of a dimeric metabolite reported previously. These compounds, together with tocopheryl-p-quinone, are postulated to arise from reactions with lipid-free radicals or peroxides in the course of the antioxidant action of vitamin E.This publication has 15 references indexed in Scilit:
- The distribution and metabolism of α-tocopherol in the ratBritish Journal of Nutrition, 1966
- Effect of Vitamin E Deficiency on Ubiquinone Levels in Rat and Rabbit LiverNature, 1965
- Antioxidant effects in biochemistry and physiologyProgress in the Chemistry of Fats and other Lipids, 1964
- Metabolic products of α-tocopherol in the livers of rats given intraperitoneal injections of [14C]-α-tocopherolBiochimica et Biophysica Acta (BBA) - Specialized Section on Lipids and Related Subjects, 1964
- Rates of Solvolysis of the p-Nitrobenzoates of exo-endo Tertiary Norborneols. A Critical Examination of the exo-endo Rate Ratio as a Basis for the Postulated Nonclassical Structure of the Norbornyl CationJournal of the American Chemical Society, 1964
- Vitamin E Oxidation with Alkaline FerricyanideScience, 1963
- Dimerization of α-tocopherol in vivoArchives of Biochemistry and Biophysics, 1963
- Conversion of d-α-tocopherol-C14 to tocopheryl-p-quinone in vivoArchives of Biochemistry and Biophysics, 1962
- Isolation and synthesis of a new metabolite of α-tocopherolBiochimica et Biophysica Acta, 1962
- METABOLISM OF VITAMIN-E .2. PURIFICATION AND CHARACTERIZATION OF URINARY METABOLITES OF ALPHA-TOCOPHEROL1956