Corrélation entre modifications de l’affinité de l’hémoglobine pour l’oxygène et métabolisme anaérobie au cours de l’exercice musculaire chez 20 silicotiques

Abstract

This study investigated the changes in hemoglobin affinity for oxygen – P50 standard [P50 (7.40)]; P50 in vivo (P50 IV), and 2,3-diphosphoglycerate concentration (2,3-DPG) – and the anaerobic metabolism during a short muscular exercise in 20 silicotic patients. P50 (7. 40) and 2,3-DPG remained unchanged at the end of the exercise but P50 IV increased significantly. A negative correlation was found between the increase in the arterial lactates and the increase in P50 IV. Such a shift to the right of the oxyhemoglobin dissociation curve probably improves the tissular oxygenation and can be regarded as a compensatory mechanism in patients with pulmonary impairment during exercise.