The mechanical and biochemical effects of pentoxifylline on the perfused rat heart
- 1 September 1980
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 36 (9), 1088-1090
- https://doi.org/10.1007/bf01965986
Abstract
Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10−4 moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.This publication has 26 references indexed in Scilit:
- Are increases in cyclic GMP levels responsible for the negative inotropic effects of acetylcholine in the heart?Biochemical and Biophysical Research Communications, 1977
- Cyclic AMP and cyclic GMP may play opposing roles in influencing force of contraction in mammalian myocardiumNature, 1976
- Stimulation of calcium accumulation in cardiac sarcolemma by protein kinaseCanadian Journal of Biochemistry, 1976
- Dissociations between changes in myocardial cyclic adenosine monophosphate and contractility.Circulation Research, 1975
- Relaxing effects of catecholamines on mammalian heartThe Journal of Physiology, 1972
- Influence of Caffeine and other Methylxanthines on Mechanical Properties of Isolated Mammalian Heart Muscle: EVIDENCE FOR A DUAL MECHANISM OF ACTIONCirculation Research, 1972
- Cyclic AMP and calcium uptake of the sarcoplasmic reticulum in relation to increased rate of relaxation under the influence of catecholaminesCardiovascular Research, 1970
- Mechanism of Action of Epinephrine and Glucagon on the Canine Heart: EVIDENCE FOR INCREASE IN SARCOTUBULAR CALCIUM STORES MEDIATED BY CYCLIC 3',5'-AMPCirculation Research, 1969
- Some Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)Circulation, 1968
- An Improved Method for Fluorimetric Determination of Small Amounts of Adrenaline and Noradrenaline in Plasma and TissuesActa Physiologica Scandinavica, 1963