Time Course of Enzyme Escape via Heart Lymph Following Myocardial Infarction in the Dog

Abstract

The activities of the four myocardial enzymes aspartate aminotransferase (also known as GOT), alanine aminotransferase (GPT), lactate dehydrogenase (LDH), and creatine kinase (CPK) were measured in dog heart lymph following myocardial infarction. The activity of all enzymes increased to very high values, and the time course of activity changes was identical for all enzymes. This is interpreted as reflecting a simultaneous escape of these enzymes from damaged myocardial cells.