THE FRACTIONATION OF THE IODINE OF THE BLOOD IN THYROID DISEASE

Abstract

When the I of the blood was fractionated by the addition of 1 vol. of blood to 10 vols. of ethyl alcohol, it was found that I in organic combination of molecular wts. of 7000 and greater was retained in the so-called organic blood I fraction. Using this method, fractional I analysis of the blood from 218 patients showed the average organic I content to be as follows: primary myxedema[long dash]2.5 [gamma] %; non-toxic goiter (normal group)[long dash]5.3 [gamma] %; exophthalmic goiter (no I treatment)[long dash]10 [gamma] %; exophthalmic goiter (on I)[long dash]8.1 [gamma] %; non-toxic goiter (on I)[long dash]8.7 [gamma] %; Compared with the normal, the organic blood I was found to be decreased in patients with primary myxedema and increased in patients with exophthalmic goiter. In patients with exophthalmic goiter, treatment with I resulted in a decrease in the organic blood I, while in the non-toxic goiter group, an increase in organic blood I was found. The time of blood I analysis relative to the time and extent of I adm. may have an important bearing on these results.