A Biochemical Assessment of the Neurotoxicity of the Radiosensitizing Drug Misonidazole in the Rat
- 1 January 1981
- journal article
- Published by Taylor & Francis in Clinical Toxicology
- Vol. 18 (12), 1411-1426
- https://doi.org/10.3109/15563658108990350
Abstract
We have obtained biochemical evidence that misonidazole when administered in large doses to rats produces a sparse dying-back peripheral neuropathy and degenerative changes in the trigeminal ganglia and cerebellum. In our experience these neurotoxic effects of misonidazole cannot be detected reliably by the use of simple behavioural and functional tests, e.g., inclined plane and narrowing bridge tests (Rose and Dewar, unpublished results). Therefore, these methods would be of limited use in the neurotoxicity screening of misonidazole analogues. On the other hand, the biochemical approach provides a convenient quantitative method which could be used as the basis for comparing the neurotoxicity of other candidate radiosensitizing drugs.Keywords
This publication has 11 references indexed in Scilit:
- Radiosensitizers in the treatment of squamous cell carcinoma of the head and neckClinical Otolaryngology, 1977
- Clinical testing of the radiosensitizer Ro 07-0582: Experience with multiple dosesBritish Journal of Cancer, 1977
- Clinical Phase I Study of the Hypoxic Cell Radiosensitizer RO-07-0582, A 2-Nitroimidazole DerivativeRadiology, 1977
- Metronidazole neuropathy.Journal of Neurology, Neurosurgery & Psychiatry, 1976
- BIOCHEMICAL STUDIES ON DEGENERATIVE NEUROLOGICAL DISORDERS: 1. ACUTE EXPERIMENTAL ENCEPHALITISJournal of Neurochemistry, 1974
- ULTRASTRUCTURAL STUDIES OF THE DYING-BACK PROCESSJournal of Neuropathology and Experimental Neurology, 1974
- Peripheral Neuropathy Caused by Chemical AgentsCRC Critical Reviews in Toxicology, 1973
- The effects of methyl-mercury-dicyandiamide on the peripheral nerves and spinal cord of ratsActa Neuropathologica, 1971
- QUANTITATIVE BIOCHEMICAL STUDIES OF WALLERIAN DEGENERATION IN THE PERIPHERAL AND CENTRAL NERVOUS SYSTEMS—IIJournal of Neurochemistry, 1959
- Chemical studies of peripheral nerve during Wallerian degeneration. 5. β-GlucuronidaseBiochemical Journal, 1952