Previous studies showed that approximately 40% of the [human] corneal endothelial cells can be lost at the time of intraocular lens insertion. Momentary contact between the methacrylate surface and the endothelial cells [of rabbits] caused an adhesion between these surfaces and results in extensive cell damage upon separation of the surfaces [as seen in scanning electron microscopy]. This type of damage appears to be due to a biophysical interaction between these surfaces and may be avoidable by altering the surface of the lens.