Effect of Nitroprusside (Nitric Oxide) on Endogenous Dopamine Release from Rat Striatal Slices
- 1 September 1992
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 59 (3), 932-935
- https://doi.org/10.1111/j.1471-4159.1992.tb08332.x
Abstract
It is becoming apparent that the synthesis of nitric oxide (NO) from l-arginine not only explains endothelium-dependent vascular relaxation, but is a widespread mechanism for the regulation of cell function and communication. We examined the role of NO on the endogenous dopamine (DA) release from rat striatum. Nitroprusside, in the concentration range of 3–100 μM, induced a dose-dependent increase in the endogenous DA release from rat striatal slices. The maximal response was 330% over the baseline release. A higher concentration of nitroprusside (300 μM) produced an inhibitory effect on the spontaneous release of DA. l-Arginine (10 and 100 μM), a substrate in the NO-forming enzyme system, also produced an elevation of DA release. l-Arginine-induced DA release was attenuated by NG-monomethyl-l-arginine, an inhibitor of NO synthase. NADPH (1 μM), a cofactor of NO synthase, enhanced l-arginine-induced DA release. These results suggest a possible involvement of NO in the DA release process in rat striatum.Keywords
This publication has 12 references indexed in Scilit:
- Glutamate, nitric oxide and cell-cell signalling in the nervous systemTrends in Neurosciences, 1991
- Localization of nitric oxide synthase indicating a neural role for nitric oxideNature, 1990
- Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.Proceedings of the National Academy of Sciences, 1989
- NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slicesEuropean Journal of Pharmacology: Molecular Pharmacology, 1989
- Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.Proceedings of the National Academy of Sciences, 1989
- A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cellsBiochemical and Biophysical Research Communications, 1989
- Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brainNature, 1988
- Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediateBiochemistry, 1988
- Simultaneous determination of catecholamines and unconjugated 3,4-dihydroxyphenylacetic acid in brain tissue by ion-pairing reverse-phase high-performance liquid chromatography with electrochemical detectionAnalytical Biochemistry, 1980
- Liquid chromatographic analysis of catecholamines routine assay for regional brain mappingLife Sciences, 1976