Thalidomide Syndrome in Monkeys

Abstract

Pregnant monkeys were treated with thalidomide after implantation but before formation of the fetal limbs. Two fetuses that were recovered from the treated females had congenital abnormalities. The thalidomide syndrome in the monkeys was manifested by amelia, phocomelia, internal hydrocephaly, facial capillary hemangioma, hypogenesis of the metatarsal bones, and anotia.