The use of serum cholinesterase in succinylcholine apnoea
- 1 May 1977
- journal article
- research article
- Published by Springer Nature in Canadian Journal of Anesthesia/Journal canadien d'anesthésie
- Vol. 24 (3), 396-400
- https://doi.org/10.1007/bf03005113
Abstract
Fifteen patients demonstrating unexpected prolonged apnoea lasting several hours after succinylcholine have been treated by a new preparation of human serum cholinesterase. Adequate spontaneous respiration was re-established in an average period of ten minutes after the injection. In 12 patients biochemical genetic examinations confirmed the presence of an atypical serum cholinesterase. In three patients none of the usual variants were found. It is therefore supposed that other unknown variants of serum cholinesterase exist which cannot hydrolyze succinylcholine. The use of serum cholinesterase in succinylcholine apnoea provided considerable relief to both patient and anaesthetist. Quinze malades ayant réagi à la succinylcholine par une apnée de plus ďune heure ont été traités par une cholinesterase serique ďorigine humaine. Le retour ďune respiration spontanée suffisante était obtenu en moyenne dix minutes après injection. Les examens biologiques et génètiques ont demonstré ľexistence ďune cholinesterase atypique chez 12 des malades. Chez les trois autre aucune des variants connues de ľenzyme n’a été trouvée. Ľhypothése de ľexistence ďautres formes de cholinesterase incapables ďhydrolyser la succinylcholine est supportée. Ľemploi de la cholinesterase serique humains est avantageuse pour le malade et pour ľanesthésiste. Aucune action secondaire n’a été observee.This publication has 14 references indexed in Scilit:
- [Succinyldicholin sensitivity resulting from genetically determined serumcholinesterase variants].1976
- Suxamethonium Apnoea Terminated with Commercial SerumcholinesteraseActa Anaesthesiologica Scandinavica, 1976
- Prolonged Apnea in an Infant Following the Use of SuccinylcholineAnesthesiology, 1973
- SUXAMETHONIUM SENSITIVITYAnnals of the New York Academy of Sciences, 1971
- AN ADDITIONAL PSEUDOCHOLINESTERASE PHENOTYPE OCCURRING IN SUXAMETHONIUM APNOEABritish Journal of Anaesthesia, 1968
- Hydrolysis of succinyldicholine and succinylmonocholine in human serum.1968
- Differential Inhibition of Human Serum Cholinesterase with Fluoride: Recognition of Two New PhenotypesNature, 1961
- The activity of various esterase inhibitors towards atypical human serum cholinesteraseBiochemical Pharmacology, 1959
- INTERNAL ROTATION: IX. THE INFRARED AND RAMAN SPECTRA OF LIQUID NORMAL ALKYL BROMIDESCanadian Journal of Chemistry, 1957
- THE INTERRELATIONSHIP OF SUCCINYLCHOLINE AND THE BLOOD CHOLINESTERASES DURING ANESTHESIAAnesthesiology, 1955