Schizophrenia: A New Approach
- 1 July 1959
- journal article
- Published by Royal College of Psychiatrists in Journal of Mental Science
- Vol. 105 (440), 653-673
- https://doi.org/10.1192/bjp.105.440.653
Abstract
In the April, 1952 issue of this journal, Osmond and Smythies (47) suggested that schizophrenia might be caused by a defect in adrenaline metabolism. They called this hypothetical adrenaline derivative “M-substance” because they endowed it with mescaline-like psychotomimetic qualities but with an effective potency nearer that of adrenaline or even the hugely powerful LSD-25. They showed that mescaline and adrenaline were sufficiently alike chemically for such an intermediate to be at least imaginable. In addition, they emphasized that the mescaline experience and the more acute and dramatic forms of schizophrenia have many similarities. They hoped that researchers would hunt diligently for our M-substance.Keywords
This publication has 24 references indexed in Scilit:
- Iproniazid Treatment and Metabolism of Labeled Epinephrine in SchizophrenicsScience, 1958
- The Case of Mr. KovishJournal of Mental Science, 1958
- NIACIN (NICOTINIC ACID) AND SERUM CHOLESTEROLJAMA, 1958
- AROMATIC METABOLISM IN SCHIZOPHRENIA II. Bidimensional Urinary ChromatogramsJournal of Nervous & Mental Disease, 1957
- Biologische Toxizitätsbestimmung pathologischer KörperflüssigkeitenEuropean Neurology, 1957
- Adrenochrome As the Cause of Schizophrenia: Investigation of Some Deductions from this HypothesisJournal of Mental Science, 1955
- A New Hallucinogen: 3,4,5-Trimethoxyphenyl-β-AminopropaneJournal of Mental Science, 1955
- Influence of nicotinic acid on serum cholesterol in manArchives of Biochemistry and Biophysics, 1955
- Schizophrenia: A New Approach. II. Result of a Year's ResearchJournal of Mental Science, 1954
- Fluorimetric Determination of Adrenaline in Blood. I. Isolation of the Fluorescent Oxidation Product of Adrenaline.Acta Pharmacologica et Toxicologica, 1949