The human osteosarcoma cell line U‐2 OS expresses a 3.8 kilobase mRNA which codes for the sequence of the PDGF‐B chain
- 31 March 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 198 (2), 344-348
- https://doi.org/10.1016/0014-5793(86)80433-1
Abstract
A cDNA clone of about 2500 base pairs was prepared from the human osteosarcoma cell line U-2 OS by hybridizing with a v-sis probe. Sequence analysis showed that this cDNA contains the coding region for the PDGF-B chain. Here we report that the mitogen secreted by these osteosarcoma cells contains the PDGF-B chain and is probably a homodimer of two B-chains.Keywords
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