THE POTENTIAL VALUE OF IMMUNOPEROXIDASE TECHNIQUES IN DIAGNOSTIC CYTOLOGY

Abstract

A slightly modified immunoperoxidase method was developed and applied to a variety of aspiration and exfoliative cytologic material. The aims of this study were: to explore the applicability of the immunoperoxidase procedure to diagnostic cytology, to define the histogenesis of neoplastic cells when morphology alone proved insufficient and to investigate the possibility of differentiating reactive from neoplastic lymphoreticular disorders by studying their immunoglobulin patterns. Apparently, the immunoperoxidase technique is applicable to cytologic material. The simplicity of the procedure, combined with its high sensitivity and excellent morphology, merits wider application of this technique to routine diagnostic cytology.