Localization of the human glucagon gene (GCG) to chromosome segment 2q36→37
- 1 January 1984
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 38 (1), 76-79
- https://doi.org/10.1159/000132034
Abstract
Hybridization of a 3H-labeled bovine glucagon cDNA plasmid to human metaphase chromosomes revealed significant labeling of the distal portion of the long arm of chromosome 2. A large portion (37%) of the cells analyzed exhibited labeling of the 2. A significant percentage (40%) of the labeled sites on the 2 were in segment 2q36→37. Therefore, the human glucagon gene (GCG), was assigned to this segment. Localization of the glucagon gene, whose chromosomal assignment was previously not known, demonstrates the general applicability of in situ hybridization as a powerful gene mapping technique.This publication has 7 references indexed in Scilit:
- Mammalian pancreatic preproglucagon contains three glucagon-related peptides.Proceedings of the National Academy of Sciences, 1983
- Polymorphic human somatostatin gene is located on chromosome 3.Proceedings of the National Academy of Sciences, 1983
- Localization of the human insulin gene to the distal end of the short arm of chromosome 11.Proceedings of the National Academy of Sciences, 1981
- Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridizationChromosoma, 1981
- The ovalbumin gene: Alleles created by mutations in the intervening sequences of the natural geneCell, 1979
- Role of glucagon in the pathogenesis of diabetes: The status of the controversyMetabolism, 1978
- Construction and characterization of new cloning vehicle. II. A multipurpose cloning systemGene, 1977