THE INFLUENCE OF CORTISONE ON SUBSTRATE UTILIZATION BY RAT HEART SLICES
- 1 July 1959
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. XXXI (III), 324-328
- https://doi.org/10.1530/acta.0.xxxi0324
Abstract
Ventricular slices were obtained from normal and cortisone treated (5 mg of cortisone acetate/100 g body weight) white adult male rats. The substrates were glucose (11mM/1), pyruvate (5 mM/1), alpha-ketoglutarate (20 mM/1) and succinate (20 mM/1). Although not statistically significant, the endogenous respiration of the cortisone treated group was depressed 13% below the mean normal values. That part of the Kreb''s cycle between pyruvate and alpha-ketoglutarate appeared impaired with cortisone administration.Keywords
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