Structural identification of a modified base in DNA covalently bound with mutagenic 3-amino-1-methyl-5H-pyrido[4,3-b]indole.
- 1 January 1979
- journal article
- letter
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 27 (4), 1058-1060
- https://doi.org/10.1248/cpb.27.1058
Abstract
A mutagen, 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2,), was reacted with DNA in the presence of rat liver microsomes. One of the modified bases was identified as 3-(C8-guanyl)amino-1-methyl-5H-pyrido[4,3-b]indole. (Applicability to carcinogenesis is discussed.).This publication has 1 reference indexed in Scilit:
- Rat liver microsome-mediated binding to DNA of 3-amino-1-methyl-5H-pyrido[4,3-b]indole, a potent mutagen isolated from tryptophan pyrolysate.Chemico-Biological Interactions, 1978