Analgesic and Antipyretic Properties of Some Aspirin Derivatives
- 1 September 1961
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 13 (1), 105-110
- https://doi.org/10.1111/j.2042-7158.1961.tb11795.x
Abstract
Several derivatives of acetylsalicylic acid have been tested for analgesic and antipyretic properties in mice and rats. o-Diphenylacetoxy benzoic acid (O-(diphenylacetyl)salicylic acid; DPA) is a superior analgesic but an inferior antipyretic to aspirin, DPA has a low toxicity: it failed to show significant anti-inflammatory or tranquillising properties. In dogs it produced only slight and transient falls in blood pressure and there was no appreciable effect on the direct or reflex muscle preparation.Keywords
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