ACTIVATED PROTEIN C INHIBITS PLATELET PROTHROMBIN-CONVERTING ACTIVITY
- 1 January 1979
- journal article
- research article
- Vol. 54 (6), 1272-1281
Abstract
Bovine platelets activated by thrombin facilitated conversion of prothrombin to thrombin in the presence of Ca ions and factor [F] Xa. Activated protein C, a vitamin-K-dependent plasma protein, inhibited this platelet prothrombin-converting activity. The inhibition was time dependent and was not reversed by increasing concentrations of FXa. Xa was able to protect platelet prothrombin-converting activity from inactivation by activated protein C. The activated protein C caused a parallel loss of FXa receptor sites and platelet prothrombin-converting activity. Activated protein C may contribute to the regulation of clotting through inactivation of platelet prothrombin-converting activity.This publication has 8 references indexed in Scilit:
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