The study of the spinal fluid in the new-born has attracted little attention until quite recent years. Indeed, when this study was begun, I was in doubt as to the true nature of the normal spinal fluid immediately after birth, and for this reason attention has been focused with equal interest on normal as well as on pathologic specimens. This work was carried out in the new-born service of the Grady Hospital, Emory Division, a hospital for the treatment of negro patients. It was begun primarily to study intracranial hemorrhage in the new-born, and to determine, if possible, the true significance of this condition. Coincident with these investigations, certain observations regarding the nature of the normal spinal fluid in these infants have been made and will be briefly reported. A total of 423 babies has been studied. A lumbar puncture was done on every infant without regard to the character