EFFECT OF SPLENECTOMY ON THE SUSCEPTIBILITY OF MICE INOCULATED WITH DIPLOCOCCUS PNEUMONIAE
Open Access
- 1 May 1966
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 123 (5), 777-794
- https://doi.org/10.1084/jem.123.5.777
Abstract
An experimental model is described which demonstrated increased susceptibility of mice to infection with D. pneumoniae following splenectomy. It was necessary to use small numbers of a particular strain of pneumococcus (D. pneumoniae type 6), intravenous infection and a particular strain of mouse (pathogen-free NCS strain). The increase in susceptibility persisted for at least 4 months after splenectomy.Keywords
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