Expression of two distinct T cell receptor alpha/beta heterodimers by an antigen-specific T cell clone.
Open Access
- 1 December 1988
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 168 (6), 2379-2384
- https://doi.org/10.1084/jem.168.6.2379
Abstract
A cytochrome c-specific, MHC-restricted T cell clone with two complete rearrangements of the same V.beta.1 gene element was shown to express two different TCR-.alpha./.beta. heterodimers. Antipeptide antisera specific for TCR C.beta.1 and C.beta.2 peptides each immunoprecipitated distinct disulfide-linked cell surface heterodimers. The clone was derived from immunized allogeneic chimeric mice, and displayed multiple Ia specificities, including the ability to recognize antigen in association with both I-Ek and I-Es Ia molecules, as well as alloreactivity to the I-Eb molecule. It will be important to determine whether each receptor contributes independently to the overall specificity of the clone.This publication has 16 references indexed in Scilit:
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