Acetylcholine. 1. Hydrolysis by hydrogen and hydroxyl ion

Abstract

The kinetics of hydrolysis of acetylcholine bromide by hydrogen ion and hydroxyl ion were followed by conventional methods. The bimolecular velocity constants,respectively,are, in 1. mole-1 sec.-1, [image] These data are very similar to those for non-ionic esters, such as methyl acetate. The A factor for kH+ is about 5 times smaller than for such esters, while for kOH it is about 20 times larger. These differences find an explanation in the ionic charge of the activated complex.