Atypical pyoderma gangrenosum with leukemia

Abstract

Pyoderma gangrenosum (PG) has been increasingly reported in association with myeloproliferative disorders. Monoclonal gammopathy, myeloma, myeloid metaplasia and polycythemia were all found in association with PG. Recently, 7 cases of PG in association with leukemia were described: 3 cases with acute myeloblastic leukemia, 2 cases with chronic myelogenous leukemia, 1 case with acute lymphoblastic leukemia and 1 case with acute leukemia of plasma cell or myeloblast origin. To these 2 cases of PG with acute myeloblastic leukemia were added. These patients often have an atypical clinical presentation for PG, with bullae and relatively superficial involvement obscuring the correct diagnosis.