Susceptibility of Mycobacterium Leprae to the Bactericidal Activity of Mouse Peritoneal Macrophages and to Hydrogen Peroxide
- 1 February 1985
- journal article
- research article
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 19 (1), 77-84
- https://doi.org/10.1099/00222615-19-1-77
Abstract
Macrophages from athymic nude mice were infected in vitro with Mycobacterium leprae to study the intracellular fate of this organism. Using the proportional bactericidal test, we have shown that the viability of M. leprae declines rapidly within these macrophages, although results of clearance experiments demonstrate that live and killed organisms are cleared at comparable rates. We have also shown that M. leprae is susceptible to the bactericidal effects of hydrogen peroxide and we suggest that hydrogen peroxide generated by macrophages is responsible for the killing of intracellular M. leprae.This publication has 10 references indexed in Scilit:
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