The expression and relation of HLA, β2 ‐microglobulin and receptor for marmoset red blood cells on man/mouse and man/Chinese hamster hybrid cells

Abstract

The expression of HLA, human and mouse β₂-microglobulin (β₂m), P red blood cell antigen and a receptor for marmoset red blood cells (MaRBC) were studied on 18 man/mouse and man/Chinese hamster hybrids. A positive correlation was found between the expression of HLA, P, and the receptor for MaRBC, which we interpret as a possible synteny between these different loci. We studied 3 hybrid clones where HLA antigens are still expressed despite the absence of human β₂m and where redistribution experiments demonstrate that HLA is associated with mouse β₂m. Synteny between HLA and the receptor for MaRBC can be a useful tool to select HLA-positive hybrid clones.