Herpesvirus saimiri strain 11 immortalizes a restricted marmoset T8 lymphocyte subpopulation in vitro.
Open Access
- 1 September 1986
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 164 (3), 926-931
- https://doi.org/10.1084/jem.164.3.926
Abstract
Herpervirus saimiri induces a fatal lymphoproliferative syndrome in a variety of New World primate species. We now show that cell lines derived from PBL of the common marmoset by in vitro-immortalization with H. saimiris strain 11 represent a remarkably restricted lymphocyte population. These cells lines have NK cell function, phenotypically express both suppressor/cytotoxic (T8) and NK cell (NKH1)-associated antigens, and express a T cell receptor. This subpopulation of lymphocytes is a very minor population of cells in the peripheral blood of common marmosets (.ltoreq. 3%). The specificity in the interaction between H. saimiri strain 11 and a subpopulation of common marmoset lymphocytes represents an example of a restricted viral lymphotropism and may have important implications for the disease induced by this virus in New World monkeys.Keywords
This publication has 9 references indexed in Scilit:
- Nononcogenic deletion mutants of herpesvirus saimiri are defective for in vitro immortalizationJournal of Virology, 1986
- Analysis of T-Cell Receptor Gene Rearrangement and Expression in Human Natural Killer ClonesScience, 1985
- Generation of monoclonal antibodies to a human natural killer clone. Characterization of two natural killer-associated antigens, NKH1A and NKH2, expressed on subsets of large granular lymphocytes.JCI Insight, 1985
- Heterogeneity of Natural Killer CellsAnnual Review of Immunology, 1984
- The human T cell receptor: Appearance in ontogeny and biochemical relationship of α and β subunits on IL-2 dependent clones and T cell tumorsCell, 1983
- Characterization of an antigen expressed by human natural killer cells.The Journal of Immunology, 1983
- T lymphocyte surface antigens in primatesEuropean Journal of Immunology, 1983
- Herpesvirus-transformed cytotoxic T-cell linesNature, 1981