Expression of Insulin-Like Growth Factor-2 Can Predict the Prognosis of Human Colorectal Cancer Patients: Correlation with Tumor Progression, Proliferative Activity and Survival
- 8 April 1998
- journal article
- Published by S. Karger AG in Oncology
- Vol. 55 (3), 242-248
- https://doi.org/10.1159/000011858
Abstract
Expression of insulin-like growth factor-2 (IGF-2) has been reported in tissue specimens and cell lines of human colorectal cancers. However, the effects of IGF-2 in colorectal cancer patients are not well known. In this study, IGF-2 staining was performed on tissue samples from 92 patients with colorectal cancer, and the relationship of IGF-2 staining to clinicopathological variables, proliferating cell nuclear antigen (PCNA) staining and patient survival was analyzed. IGF-2 staining was correlated with tumor progression, PCNA staining and patient survival. Our results suggest that IGF-2 plays an important role in tumor progression and that IGF-2 staining is useful as a prognostic factor in colorectal cancer patients.Keywords
This publication has 4 references indexed in Scilit:
- Serum carcinoembryonic antigen levels and proliferating cell nuclear antigen labeling index for patients with colorectal carcinoma: Correlation with tumor progression and survivalCancer, 1996
- Processing of insulin-like growth factor-II (IGF-II) by human breast cancer cellsMolecular and Cellular Endocrinology, 1994
- Functional identity of proliferating cell nuclear antigen and a DNA polymerase-δ auxiliary proteinNature, 1987
- Cyclin/PCNA is the auxiliary protein of DNA polymerase-δNature, 1987