Induction of sarcomas in rats by subcutaneous injection of dinitropyrenes
- 1 May 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 5 (5), 583-585
- https://doi.org/10.1093/carcin/5.5.583
Abstract
The cardnogenicities of potent mutagenic dinitropyrenes were examined by their subcutaneous injections into male F344/DuCrj rats. Animals were injected with 0.2 mg each of 1, 3- and 1, 8-dinitropyrenes (1, 3- and 1, 8-DNPs) dissolved in 0.2 ml of dimethyl sulfoxide (DMSO) twice a week for 10 weeks. In rats treated with 1, 8-DNP, sarcomas were induced at the sites of injection in all 10 animals tested between the 113th and 127th experimental days. In rats treated with 1, 3-DNP, 10 of 10 rats developed sarcomas between days 119 and 320. Some tumors induced by these chemicals were trans-plantable into the same strain of rats. No tumors developed in control rats, which received only DMSO.Keywords
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