The human preproapolipoprotein C-II gene
- 9 March 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 213 (1), 221-226
- https://doi.org/10.1016/0014-5793(87)81495-3
Abstract
The complete nucleic acid sequence of human preproapolipoprotein (apo) C-II has been determined from 2 apoC-II clones isolated from 2 different human genomic DNA libraries. The cloned fragments were approx. 14 and 18 kb long, and sequence analysis established that the apoC-II gene consists of 3338 nucleotides containing 3 intervening sequences of 2391, 167, and 298 bases. The first intron is located within the 5'-untranslated region of apoC-II and contains 4 Alu type sequences. The second intron interrupts the codon specifying amino acid —11 of the apoC-II signal peptide. The last intron, which contains a 38 bp sequence which is repeated 6 times, interrupts the codon specifying for amino acid +44 of the mature apolipoproteinKeywords
This publication has 17 references indexed in Scilit:
- The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organizationNucleic Acids Research, 1985
- Human apolipoprotein C-II: complete nucleic acid sequence of preapolipoprotein C-II.Proceedings of the National Academy of Sciences, 1984
- Analysis of the apoC-II gene in apoC-II deficient patientsBiochemical and Biophysical Research Communications, 1984
- Familial apolipoprotein CII deficiency: A preliminary analysis of the gene defect in two independent familiesHuman Genetics, 1984
- The localization of the gene for apolipoprotein C-II to chromosome 19Biochemical and Biophysical Research Communications, 1984
- Isolation and sequence of a human apolipoprotein CII cDNA clone and its use to isolate and map to human chromosome 19 the gene for apolipoprotein CII.Proceedings of the National Academy of Sciences, 1984
- Human apoHpoprotetas AI, AII, CII and CIII. cDNA sequences and mRNA abundanceNucleic Acids Research, 1984
- The Plasma Lipoproteins: Structure and MetabolismAnnual Review of Biochemistry, 1978
- Role of Specific Glycopeptides of Human Serum Lipoproteins in the Activation of Lipoprotein LipaseCirculation Research, 1970
- A specific apoprotein activator for lipoprotein lipaseBiochemical and Biophysical Research Communications, 1970