THE ENZYME CONTENT OF PANCREATIC SECRETION FOLLOWING VARIOUS STIMULANTS

Abstract

The pancreatic secretions obtained in response to stimulation by prostigmine, Na nitrate, epinine, and SI (secretin plus pancreozymin) have been studied for their enzyme composition. Na nitrate and prostigmine produced an enzyme-rich secretion, epinine, and secretin an enzyme-poor one; all enzymes detd. were equally affected by the various stimuli. The evidence is believed to indicate that sympathomimetic amines which stimulate pancreatic secretion do not do so by way of the autonomic nervous system. The similarity in the secretion obtained in response to cholinergic and vasodilator stimuli is presumptive evidence that the vagus exerts its effect on the pancreas by producing vasodilatation.