Clinical Tolerance and Catabolism of Plasmin-Treatedγ-Globulin for Intravenous Application
- 1 March 1975
- journal article
- Published by Wiley in Vox Sanguinis
- Vol. 28 (3), 157-175
- https://doi.org/10.1111/j.1423-0410.1975.tb02755.x
Abstract
Plasmin-treated gamma-globulin of placental origin was tested in clinical and laboratory studies and found to be suitable for intravenous use both for prophylactic and therapeutic purposes. Plasmin treatment of gamma-globulin (IgG) results in proteolytic cleavage of 60-70% of the molecules into Fab and Fc fragments whereas 30-40% of the molecules are plasmin resistant. The antibody spectrum of plasmin-treated gamma-globulin is similar to that of standard gamma-globulin. Catabolic properties of the plasmin-resistant portion of this preparation and of standard gamma-globulin are identical. Plasmin-treated gamma-globulin has no anticomplementary activity and its intravenous administration is well tolerated even by highly sensitive immunodeficient patients.Keywords
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