The generation of hydroxyl radicals following superoxide production by neutrophil NADPH oxidase
- 27 December 1982
- journal article
- Published by Wiley in FEBS Letters
- Vol. 150 (2), 300-302
- https://doi.org/10.1016/0014-5793(82)80755-2
Abstract
Stimulated neutrophils generate superoxide and hydroxyl radicals. A membrane‐bound NADPH oxidase, inactive in the resting state, is responsible for superoxide production. The production of hydroxyl radicals is through a secondary reaction. A Fenton‐catalysed Haber—Weiss reaction is proposed. Transferrin was used as the catalyst in this investigation.Keywords
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