Plasma Glucose, Insulin, Glucagon, and Growth Hormone in Kindreds with Maturity-Onset Type of Hyperglycemia in Young People
- 1 May 1978
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 88 (5), 595-601
- https://doi.org/10.7326/0003-4819-88-5-595
Abstract
Two kindreds affected by maturity-onset type of hyperglycemia in young people were studied. The postglucose-load hyperglycemia segregated as an autosomal dominant trait; it was always mild, never requiring insulin and generally seemed to start in the first 2 decades of life. Glucose, insulin, glucagon and growth hormone were measured during glucose-tolerance tests in patients, relatives and control subjects. Most hyperglycemic patients were found to have insulin deficiency. There was no correlation between the age of the patients and insulin secretion. Plasma glucagon and growth hormone were normal. Maturity-onset type of hyperglycemia in young people may be a frequent type of hyperglycemia, and its identification generally depends on the presence of a strong family history. The recognition of maturity-onset type of hyperglycemia in young people as a specific disease different from juvenile, insulin-dependent diabetes is important, especially to prevent unnecessary use of insulin in hyperglycemic children.This publication has 4 references indexed in Scilit:
- HLA in maturity-onset type of hyperglycemia in the youngArchives of Internal Medicine, 1978
- Insulin Secretion in Response to Glycemic Stimulus: Relation of Delayed Initial Release to Carbohydrate intolerance in Mild Diabetes Mellitus*JCI Insight, 1967
- Coated Charcoal Immunoassay of InsulinJournal of Clinical Endocrinology & Metabolism, 1965
- A Simple Immunoassay for Insulin: Application to Human and Dog PlasmaJournal of Clinical Endocrinology & Metabolism, 1963