Mycobacterium tuberculosisMicrobiologic and Clinical Treatment Outcomes in a Randomized Trial of Immediate versus CD4+‐Initiated Antiretroviral Therapy in HIV‐Infected Adults with a High CD4+Cell Count

Abstract

In a prospective randomized, controlled trial in Uganda comparing the efficacy of antiretroviral therapy during tuberculosis therapy with the efficacy of tuberculosis therapy alone in HIV-infected patients with tuberculosis who have a CD4⁺ cell count >350 cells/µL, it was found that antiretroviral therapy did not accelerate microbiologic, radiographic, or clinical responses to tuberculosis therapy: 18% of participants had sputum smears positive for Mycobacterium tuberculosis after 5 months of tuberculosis therapy, despite having had negative culture results. Trial registration. ClinicalTrials.gov identifier: NCT00078247.