Pharmacokinetics of ofloxacin and theophylline alone and in combination

Abstract

Summary The pharmacokinetic interactions of ofloxacin (2×200 mg) and theophylline (3×200 mg) were investigated in 12 healthy volunteers over a period of two weeks. In the first week, theophylline was given over five days to reach a steady state. In the second week, the combination of theophylline and ofloxacin was applied. C_max, t_max, AUC_0–8, the serum elimination constant and serum half-life of theophylline were not changed when theophylline was given alone or in combination with ofloxacin. The kinetic parameters of ofloxacin were in accordance with data from the literature.