Acid Secretory Potency and Elimination of the 15-Leucine Gastrin-17 Analogue in Man
- 1 April 1981
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Gastroenterology
- Vol. 16 (3), 437-440
- https://doi.org/10.3109/00365528109181994
Abstract
The effect on gastric acid secretion and the elimination of a commercially available synthetic human gastrin analogue (15-Leucine Synthetic Human Gastrin I, 15-LSG) were studied in six healthy human subjects. On a molar basis acid secretory efficacy was approximately four times greater than pentagastrin and secretory potency ten times greater. Elimination of 15-LSG was bi-exponential, with half-lives of 5.2 ± 0.8 and 25.9 ± 7.0 min. Metabolic clearance rate was 6.9 ± 0.4 ml/kg-min and volume of distribution 52 ml/kg.Keywords
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