A noninvasive procedure to detect muscle weakness in the mdx mouse
- 1 June 1990
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 13 (6), 480-484
- https://doi.org/10.1002/mus.880130603
Abstract
The forward pulling tension exerted by individual mice was measured nearly isometrically in a simple apparatus designed to determine whole body tension (WBT). WBT determinations on control (C57BI10/SnJ) and experimental (C57BI10-mdx) mice indicate muscle weakness which lasts throughoout the lifespan of mdx mice. Direct muscle stimulation experiments in vivo also showed significant decreases in peak twitch and tetanic tensions in adult mdx muscle with no obvious alterations in twitch time course or in twitch: tetanus rations. We suggest that the noninvasive WBT procedure may be used to partially assess various therapies on this murine model of Duchenne muscular dystrophy.Keywords
This publication has 19 references indexed in Scilit:
- Serum CK, calcium, magnesium, and oxidative phosphorylation in mdx mouse muscular dystrophyMuscle & Nerve, 1988
- Immunoelectron microscopic localization of dystrophin in myofibresNature, 1988
- Immunostaining of skeletal and cardiac muscle surface membrane with antibody against Duchenne muscular dystrophy peptideNature, 1988
- Is Nebulin the Defective Gene Product in Duchenne Muscular Dystrophy?New England Journal of Medicine, 1987
- Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy geneNature, 1986
- Muscle development in mdx mutant miceMuscle & Nerve, 1984
- Slowing of twitch of dystrophic mouse muscle is partially due to altered activity patternMuscle & Nerve, 1983
- Slowing of fast-twitch muscle in the dystrophic mouseExperimental Neurology, 1981
- Duchenne dystrophyNeurology, 1978
- Disorder of muscle contraction processes in sex-linked (Duchenne) muscular dystrophy, with correlative electromyographic study of myopathic involvement in small hand musclesAmerican Journal Of Medicine, 1968