Evidence for Rapid Turnover of Norepinephrine in Rat Heart and Brain
- 1 October 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 111 (1), 79-81
- https://doi.org/10.3181/00379727-111-27710
Abstract
Administration of an indolyl-alkyl-arylpiperazine (Win 18501–2) to rats depletes the norepinephrine content of heart and brain without affecting brain serotonin. Maximum depletion was observed within 3 hours with return to normal values within 8 hours. These findings suggest that the turnover of heart and brain norepinephrine in the rat is very rapid.Keywords
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