Women with Anorexia Nervosa: Finite Element and Trabecular Structure Analysis by Using Flat-Panel Volume CT
- 1 October 2010
- journal article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 257 (1), 167-174
- https://doi.org/10.1148/radiol.10100222
Abstract
Purpose To use finite element modeling based on flat-panel volume computed tomography (CT) and bone mineral density (BMD) provided by dual-energy x-ray absorptiometry (DXA) to compare bone failure load, stiffness, and trabecular structure in women with anorexia nervosa (AN) and age-matched normal-weight control subjects. Materials and Methods The study was approved by the institutional review board and complied with HIPAA guidelines. Informed consent was obtained. Fourteen women, eight with AN (mean age, 26.6 years) and six control subjects (mean age, 26.3 years), underwent flat-panel volume CT of the distal radius to determine apparent trabecular bone volume fraction (BV/TV), apparent trabecular number (TbN), apparent trabecular thickness (TbTh), and apparent trabecular separation (TbSp). Bone strength and stiffness were calculated from uniaxial compression tests by using finite element models created from flat-panel volume CT. DXA was used to determine BMD of the radius, lumbar spine, and hip. Means ± standard deviations of all variables were calculated for both groups and compared (Student t test). Univariate regression analysis and stepwise regression modeling were performed. Results Patients with AN had lower values for stiffness (284.77 kN/mm ± 76.14 vs 389.97 kN/mm ± 84.90, P = .04), failure load (4.98 kN ± 1.23 vs 7.01 kN ± 1.52, P = .02), BV/TV (0.32% ± 0.09 vs 0.44% ± 0.02, P = .007), and TbN (1.15 mm−3 ± 0.20 vs 1.43 mm−3 ± 0.13, P = .008) and higher values for TbSp (0.62 mm ± 0.20 vs 0.40 mm ± 0.04, P = .02) compared with normal-weight control subjects. TbTh was lower in women with AN (P = .1). BMD measurements were significantly lower for the AN group. BMD measurements and trabecular parameters (except TbTh) correlated with stiffness and failure load (r = 0.58 to 0.83). Conclusion Failure load and stiffness are abnormal in women with AN compared with those in normal-weight control subjects and correlate with BMD and trabecular parameters. © RSNA, 2010Keywords
This publication has 25 references indexed in Scilit:
- Distal Radius in Adolescent Girls with Anorexia Nervosa: Trabecular Structure Analysis with High-Resolution Flat-Panel Volume CTRadiology, 2008
- Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element methodBone, 2008
- Finite Element Analysis Based on In Vivo HR-pQCT Images of the Distal Radius Is Associated With Wrist Fracture in Postmenopausal WomenJournal of Bone and Mineral Research, 2008
- Does weight gain induce cortical and trabecular bone regain in anorexia nervosa? A two-year prospective studyBone, 2007
- Effects of Thresholding Techniques on μCT-Based Finite Element Models of Trabecular BoneJournal of Biomechanical Engineering, 2006
- Trabecular Bone Structure of the Distal Radius, the Calcaneus, and the SpineInvestigative Radiology, 2004
- Image-Based Micro-Finite-Element Modeling for Improved Distal Radius Strength DiagnosisJournal of Clinical Densitometry, 2004
- Biomechanics of Trabecular BoneAnnual Review of Biomedical Engineering, 2001
- High-Resolution Three-Dimensional-pQCT Images Can Be an Adequate Basis for In-Vivo μFE Analysis of BoneJournal of Biomechanical Engineering, 2000
- Osteoporosis in Women with Anorexia NervosaNew England Journal of Medicine, 1984