Active Ion Transport in Dog Tongue: A Possible Role in Taste
- 27 November 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 214 (4524), 1039-1041
- https://doi.org/10.1126/science.7302576
Abstract
An in vitro preparation of the dorsal epithelium of the dog tongue actively transports ions, producing a transepithelial potential difference characteristic of the ions and their concentration. Hypertonic sodium chloride solutions generally cause increased potentials and short-circuit currents and reduced resistances when placed on the mucosal surface. This hypertonic flux is eliminated by ouabain and is not found in ventral lingual epithelia. When either sodium acetate or tetramethylammonium chloride is substituted for sodium chloride in the mucosal medium, the currents are diminished but their sum at a given concentration approximates that for sodium chloride at the same concentration. This result suggests a current composed of inward sodium ion movement and outward chloride ion movement. Actively regulated potentials and currents, whether generated in the taste buds or in supporting cells, may be important in both normal chemotransduction and in taste responses evoked by currents passing through the tongue.Keywords
This publication has 10 references indexed in Scilit:
- An analysis of the effects of stimulus transport and membrane charge on the salt, acid and water-response of mammalsChemical Senses, 1980
- A model for the stimulation of taste receptor cells by saltBiophysical Journal, 1976
- Physicochemical studies of taste reception. I. Model membrane simulating taste receptor potential in response to stimuli of salts, acids and distilled waterBiochimica et Biophysica Acta (BBA) - Biomembranes, 1974
- NaCl thresholds in man: Thresholds for water taste or NaCl taste?Journal of Comparative and Physiological Psychology, 1974
- Permeability of tongue epithelium and its relation to tasteAmerican Journal of Physiology-Legacy Content, 1971
- Effects of D2O and Osmotic Gradients on Potential and Resistance of the Isolated Frog SkinThe Journal of general physiology, 1964
- Responses of isolated bronchial muscle to ganglionically active drugsThe Journal of Physiology, 1958
- ELECTROLYTE DISTRIBUTION AND ACTIVE SALT UPTAKE IN FROG SKINThe Journal of general physiology, 1955
- Active Transport of Sodium as the Source of Electric Current in the Short‐circuited Isolated Frog Skin.Acta Physiologica Scandinavica, 1951
- Ein Beitrag zum Problem des Ruhestroms der FroschhautPflügers Archiv - European Journal of Physiology, 1941