Effects of ventrolateral thalamic nucleus cooling on initiation of forelimb ballistic flexion movements by conditioned cats
- 1 February 1979
- journal article
- research article
- Published by Springer Nature in Experimental Brain Research
- Vol. 34 (3), 435-452
- https://doi.org/10.1007/bf00239141
Abstract
Five cats were trained to perform a forelimb ballistic flexion on a reaction time paradigm including an upper limit of about 400 ms for reinforcement (food pellets). They were implanted with a cyrogenic probe thermically insulated, except at the tip, by a vacuum jacket (outer diameter, 1.1 mm). Four cats had the probe inserted into the ventrolateral thalamic nucleus (VL), contralateral to the moving limb. During cooling they showed increased reaction times, which remained constant throughout daily sessions performed during many weeks, independent of the foreperiod but varying from 25 to 100 ms according to the subject. The temperatures used to upset the reaction times varied from +10 ° C to −8 ° C, depending on the localisation of the probe and on the insulation of the silver tip used to prevent nervous tissue reaction, but for each subject the reaction times always increased when the temperature was lowered. The fifth cat, with a probe inserted between VL and the Centre Median, showed a decrease of reaction times on cooling to 0 ° C and an increase of the reaction times for a cooling at −10 ° C. For one of the four cats with a probe properly inserted into the VL, strain-gauges were stuck on the lever to measure the latency of the decrease of the pressure exerted by the subject when the subject initiated the forelimb flexion in response to the CS. Reaction times and latencies of pressure changes were closely correlated with the movement onset, and they were equally delayed during cooling. This result demonstrates that it is not by slowing down movement velocity that reaction times are upset during VL cooling but by delaying the movement onset.Keywords
This publication has 35 references indexed in Scilit:
- Dentate cooling in monkeys performing a visuo-motor pointing taskNeuroscience Letters, 1978
- Cerebellar participation in generation of prompt arm movementsJournal of Neurophysiology, 1977
- The cerebello-thalamo-cortical pathway. Topographical investigation at the unitary level in the catExperimental Brain Research, 1977
- Timing of activity in cerebellar dentate nucleus and cerebral motor cortex during prompt volitional movementBrain Research, 1975
- Cerebrocerebellar communication systems.Physiological Reviews, 1974
- The activity of dentate neurons during an arm movement sequenceBrain Research, 1974
- Temperature effects on resting potential and spike parameters of cat motoneuronsExperimental Brain Research, 1974
- Cerebellar output: Properties, synthesis and usesBrain Research, 1972
- Nouveau dispositif pour le refroidissement localise des structures nerveusesElectroencephalography and Clinical Neurophysiology, 1972
- The effect of pyramidal lesions on response latency in catsBrain Research, 1967