Mood Disorders and Dysfunction of the Hypothalamic-Pituitary-Adrenal Axis in Multiple Sclerosis
Open Access
- 1 January 1998
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 55 (1), 66-72
- https://doi.org/10.1001/archneur.55.1.66
Abstract
CONCOMITANT with the deemphasis of euphoria, depression is now considered as the chief psychiatric implication of multiple sclerosis (MS). The lifetime rate of depression has been estimated between 27% and 54%.1-5 Minor depressive symptoms and anxiety are even more common.4 The pathophysiological basis for a possible relationship between depression and MS is unknown.Keywords
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