The development of tolerance to morphine in the rat
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 54 (2), 197-201
- https://doi.org/10.1007/bf00426780
Abstract
Tolerance to various effects of morphine in the rat can be quantified by means of a shift of semilogarithmic dose-response curves. Tolerance to analgesia (hot plate, acetic acid writhing), catalepsy, and the tilted plane develops in a closely similar manner. Also, the stimulating effects of about 1 mg/kg morphine-HCl tested in an open-field procedure are somewhat less pronounced in chronically treated rats than in naive ones. There is no correlation between tolerance development and the acute ED50 of different tests.Keywords
This publication has 9 references indexed in Scilit:
- Quantitative assessment of tolerance to and dependence on morphine in miceNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1977
- Mechanisms of Tolerance to and Dependence on Narcotic Analgesic DrugsAnnual Review of Pharmacology, 1975
- Morphine induced stereotypic behavior in ratsBehavioral Biology, 1975
- Tolerance to the behavioral and neurochemical effects of haloperidol and morphine in rats chronically treated with morphine or haloperidolNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1974
- Behavioural and pharmacological studies on morphine-induced excitation of rats. Possible relation to brain catecholaminesPsychopharmacology, 1973
- Disturbed patterns of behaviour in morphine tolerant and abstinent ratsBritish Journal of Pharmacology, 1971
- Behavioural effects in rats of morphine and amphetamine and of a combination of the two drugsPsychopharmacology, 1970
- Tolerance to and physical dependence on morphine in ratsPsychopharmacology, 1963