The development of tolerance to morphine in the rat
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 54 (2), 197-201
- https://doi.org/10.1007/bf00426780
Abstract
Tolerance to various effects of morphine in the rat can be quantified by means of a shift of semilogarithmic dose-response curves. Tolerance to analgesia (hot plate, acetic acid writhing), catalepsy, and the tilted plane develops in a closely similar manner. Also, the stimulating effects of about 1 mg/kg morphine-HCl tested in an open-field procedure are somewhat less pronounced in chronically treated rats than in naive ones. There is no correlation between tolerance development and the acute ED50 of different tests.This publication has 10 references indexed in Scilit:
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