Histamine Production by Transplantable Argyrophilic Gastric Carcinoid of Praomys (Mastomys) natalensis
- 23 October 1970
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 170 (3956), 454-455
- https://doi.org/10.1126/science.170.3956.454
Abstract
A transplantable argyrophilic gastric carcinoid of Praomys (Mastomys) natalensis contained appreciable amounts of histamine. Dialyzed, microsome-free supernatant of tumor tissue produced definite amounts of histamine in the presence of L-histidine and pyridoxal phosphate. These findings may relate to hypersecretion of gastric acid and formation of multiple ulcers in the stomach and duodenum of Mastomys bearing carcinoids.Keywords
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