PRODUCTION OF ESTRUS
- 11 November 1933
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 101 (20), 1553-1556
- https://doi.org/10.1001/jama.1933.02740450027007
Abstract
There are three distinct substances in the human placenta that are capable of producing estrus precociously when administered to immature rats or mice; the first is ether soluble, the second ether insoluble but alcohol soluble, the third alcohol insoluble. From the ether-soluble fraction Browne,1 in our laboratory isolated an active principle in crystalline form; it proved to be identical with trihydroxy-estrin or theelol, whose most characteristic physiologic property is that, while highly active in immature intact rodents, it is relatively less active in adult or immature ovariectomized animals; possibly, as we have suggested, because in the presence of ovarian tissue it undergoes conversion into some more active modification such as ketohydroxyestrin (theelin). The active principle of the second fraction has been termed emmenin in a previous report;2 it displays the same characteristic property, and we believe it to be a compound of trihydroxy-estrin with some unknown substance thatThis publication has 7 references indexed in Scilit:
- ON THE EFFECT OF THE ANTERIOR PITUITARY-LIKE HORMONE ON THE OVARY OF THE HYPOPHYSECTOMIZED RATEndocrinology, 1933
- THE PREPARATION, IDENTIFICATION AND ASSAY OF PROLACTIN—A HORMONE OF THE ANTERIOR PITUITARYAmerican Journal of Physiology-Legacy Content, 1933
- SEX HORMONES OF THE ANTERIOR LOBE OF THE HYPOPHYSISAmerican Journal of Physiology-Legacy Content, 1933
- THE SPECIFICITY IN THE ACTION OF THE ANTERIOR PITUITARY OF DIFFERENT MAMMALS AS WELL AS OF URINE OF PREGNANT WOMEN ON THE SEX ORGANS AND THYROID GLANDS OF IMMATURE FEMALE GUINEA PIGS*Endocrinology, 1932
- RELATION OF PROLAN TO THE ANTERIOR HYPOPHYSEAL HORMONESAmerican Journal of Physiology-Legacy Content, 1932
- Further observations on an ovary-stimulating hormone of the placenta1930
- THE DISABILITIES CAUSED BY HYPOPHYSECTOMY AND THEIR REPAIRJAMA, 1927