Intercellular communication and tissue growth: VII. A cancer cell strain with retarded formation of permeable membrane junction and reduced exchange of a 330-dalton molecule
- 1 December 1976
- journal article
- research article
- Published by Springer Nature in The Journal of Membrane Biology
- Vol. 30 (1), 175-186
- https://doi.org/10.1007/bf01869666
Abstract
A cancer (hepatoma) cell strain is described in which the formation of junctional membrane channels is abnormally slow. The development of electrical junctional coupling following the establishment of contact between these (reaggregated) cells is at least 15 times slower than that between their normal counterparts; and junctional transfer of fluorescein eventually develops, but only in about 5% of the contacts (as against 100% normally). This deviant membrane behavior is interpreted as a retardation in the process of accretion of junctional membrane channels. Its possible etiological role in defective growth regulation is discussed.This publication has 30 references indexed in Scilit:
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