The effects of neuroleptics on neuropsychological test results of schizophrenics

Abstract

This paper reviews the literature investigating antipsychotic medication effects on the neuropsychological test results of schizophrenics. A synthesis of findings suggests that specific cognitive functions are differentially affected. The toxic effects of dopamine and muscarinic blockade adversely affect find motor coordination and memory respectively. A decrement in maze performance is also suggested, raising the possibility that frontal lobe functioning is adversely affected by neuroleptic treatment. There is equivocal evidence for medication effects on primary language skills, IQ. Halstead Reitan scores, reaction time, and CPT performance. Antipsychotics probably do not have large effects on cognitive inhibition and visual-motor coordination. The implication of these findings for the understanding of schizophrenia are discussed.